My scholar reveals the existence and regulatory mechanism of the "tangible" biological clock

Tech 2023-06-06 09:15:34 Source: Network

Science and Technology Daily News (Reporter Zhang Qiang, Correspondent Wang Di, Li Meihua): For a long time, the biological clock has been considered an invisible "clock" in organisms, precisely regulating important physiological functions. Recently, the research team of Li Huiyan and the team of Academician Zhang Xuemin from the Academy of Military Medicine, military science, found that the primary cilia of neurons in the brain's superior optic chiasm nucleus (SCN) are organelle that regulate the body's rhythm, revealing the existence of a "visible" biological clock and its rhythm regulation mechanism

Science and Technology Daily News (Reporter Zhang Qiang, Correspondent Wang Di, Li Meihua): For a long time, the biological clock has been considered an invisible "clock" in organisms, precisely regulating important physiological functions. Recently, the research team of Li Huiyan and the team of Academician Zhang Xuemin from the Academy of Military Medicine, military science, found that the primary cilia of neurons in the brain's superior optic chiasm nucleus (SCN) are organelle that regulate the body's rhythm, revealing the existence of a "visible" biological clock and its rhythm regulation mechanism. The top international academic journal "Science" has published research papers related to this major original breakthrough online.

It is understood that the SCN region is the command center of circadian rhythm. Researchers found that neurons in this region have primary cilia, which are like cell "antenna". The research team has been engaged in the research of cilia organelle for a long time, revealing a series of important laws of primary cilia generation and disassembly. In this study, by continuously observing the ciliary structure of brain slices, researchers were surprised to discover a special phenomenon of ciliary rhythmic changes, and after years of exploration, it was revealed that cilia have the function of regulating rhythm.

Li Huiyan metaphorically said, "This' antenna 'structure stretches and retracts every 24 hours, like the' pointer 'of the biological clock, which can adjust the body's rhythm and time difference." Researchers further found that the mechanism by which cilia regulate the body's rhythm is by regulating the co frequency resonance of a large number of neurons in the SCN region, which is the most exciting scientific discovery for them.

According to reports, it is generally believed that the sleep, wakefulness and eating behaviors of human beings with circadian rhythm are attributed to the role of the biological clock. With the increasing competition and work pressure in society, about one-third of people worldwide suffer from rhythm disorders. If the rhythm is abnormal, it can cause sleep disorders, metabolic disorders, decreased immunity, and even serious diseases such as tumors, diabetes, and mental disorders.

Li Huiyan said, "The discovery of cilia regulating rhythms has also opened up a new path for the development of new drugs for rhythm regulation, making it possible for the body to quickly respond and adapt to various complex environments

Experts believe that the discovery of the "tangible" biological clock is a milestone in understanding the essence of rhythm and the treatment of diseases caused by rhythm disorders.

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